Guitar Freaks V6 includes over 500 songs, making it the the largest collection of songs in a Guitar Freaks release so far. The songs comprise a wide range of genres including rock and pop.
Gameplay remains the same from previous titles, with the player using a simulated guitar controller to play the notes of a chosen songs guitar part as they are displayed on the screen. The machine can be played by one or two players, and can also be linked to Drum Mania V6. Also new to Guitar Freaks V6 is 'Quest Mode'.